GOJI-BEERE
Aktuelle wissenschaftliche Studien | 136-155
136: Wei Sheng Yan Jiu. 1999 Mar 30;28(2):115-6.
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[The protective effects of total flavonoids from Lycium Barbarum L. on lipid peroxidation of liver mitochondria and red blood cell in rats]
[Article in Chinese]
Huang Y, Lu J, Shen Y, Lu J.
Department of Nutrition and Food Hygiene, Faculty of Preventive Medicine, Ningxia Medical College, Yinchuan 750004, China.
The protective effects of total flavonoids from Lycium Barbarum L. (TFL) on lipid peroxidation in mitochondria and red blood cells (RBC) induced by oxygen radicals produced by Fe2+ cysteine system were investigated. The mitochondria lipid peroxidation (measured as malondialdehyde, MDA) was significantly inhibited by TFL with a dose-response relation between the concentrations of 0.025 and 2.0 mg/ml, and the fluidity of mitochondria membrane was also protected effectively. It was observed by scan electron microscope, that the shape of RBC in the Fe2+ system was damaged significantly. The shape of RBC was remained with the addition of TFL.
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PMID: 11938998 [PubMed - indexed for MEDLINE]
137: Biol Pharm Bull. 2002 Mar;25(3):390-2.
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Zeaxanthin dipalmitate from Lycium chinense fruit reduces experimentally induced hepatic fibrosis in rats.
Kim HP, Lee EJ, Kim YC, Kim J, Kim HK, Park JH, Kim SY, Kim YC.
College of Pharmacy, Seoul National University, Korea.
We previously reported that zeaxanthin dipalmitate (ZD), a carotenoid from Lycium chinense fruit, reduces myofibroblast-like cell proliferation and collagen synthesis in vitro. To determine whether ZD might reduce the severity of hepatic fibrosis in an animal model, hepatic fibrosis was induced in rats by bile duct ligation/scission (BDL) for a period of 6 weeks. Treatment of BDL rats with ZD at a dose of 25 mg/kg body weight significantly reduced the activities of aspartate transaminase (p<0.05) and alkaline phosphatase (p<0.001) in serum. Furthermore, collagen deposition was significantly reduced as assessed by the Sirius Red binding assay in BDL rats administered ZD at the dose of 25 mg/kg body weight (p<0.01). In addition, the levels of thiobarbituric acid-reactive substances and 4-hydroxyproline were reduced when BDL rats received ZD at the dose of 25 mg/kg body weight. These results showed that ZD effectively inhibited hepatic fibrosis in BDL rats, at least in part via its antioxidative activity.
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PMID: 11913541 [PubMed - indexed for MEDLINE]
138: Ann Pharmacother. 2001 Oct;35(10):1199-201.
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Possible interaction between warfarin and Lycium barbarum L.
Lam AY, Elmer GW, Mohutsky MA.
Department of Pharmacy, University of Washington, Seattle 98104-3031, USA. aylam@u.washington.edu
OBJECTIVE: To describe a patient who was stabilized on warfarin and developed an elevated international normalized ratio (INR) after drinking a concentrated Chinese herbal tea. Additionally, to determine the effect of the tea on CYP2C9, the isoenzyme responsible for the metabolism of S-warfarin. CASE SUMMARY: An elevated INR of 4.1 was observed in a 61-year-old Chinese woman, previously stabilized on anticoagulation therapy (INR 2-3). With no changes in her other medications or lifestyle, a review of her dietary habits revealed four days of drinking a concentrated Chinese herbal tea made from Lycium barbarum L. fruits (3-4 glasses daily) prior to her clinic visit Warfarin was withheld for one day and then resumed at a lower weekly dose. She discontinued the tea, while maintaining consistency with medications and dietary habits. A follow-up INR seven days later was 2.4, and seven subsequent INR values were in the 2.0-2.5 range. DISCUSSION: L barbarum L. (family Solanaceae) is a commonly used Chinese herb considered to have a tonic effect on various organs. Any impact of an herbal product on the metabolism of S-warfarin, the enantiomer responsible for most of the anticoagulant activity, could alter the INR values. An herbal-drug interaction was suspected in this case. In vitro evaluation showed inhibition of S-warfarin metabolism by CYP2C9 by the tea of L. barbarum L.; however, the inhibition observed was weak, with a dissociation constant (Ki) value of 3.4 mg/mL, suggesting that the observed interaction may be caused by factors other than the CYP450 system. CONCLUSIONS: There is a potential herbal-drug interaction between warfarin and L. barbarum L., based on an increased INRvalue noted with concurrent use. Thus, combination of L. barbarum L. and warfarin should be avoided. Vigilance is needed with other herbal combinations taken with drugs of narrow therapeutic indices.
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PMID: 11675844 [PubMed - indexed for MEDLINE]
139: J Asian Nat Prod Res. 1999;1(4):259-67.
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Structure elucidation of glycan of glycoconjugate LbGp3 isolated from the fruit of Lycium barbarum L.
Huang LJ, Tian GY, Ji GZ.
Shanghai Institute of Organic Chemistry, Academia Sinica, China.
The structure of the repeat unit of the glycan of glycoconjugate LbGp3 with pronounced immunoactivity, isolated from the fruit of Lycium barbarum L. was elucidated based on methylation analysis, partial acid hydrolysis and 1H, 13C NMR spectroscopy of the original glycan and products of its partial hydrolysis.
PMID: 11523546 [PubMed - indexed for MEDLINE]
140: Planta Med. 2001 Jun;67(4):379-81.
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Differentiation of Lycium barbarum from its related Lycium species using random amplified polymorphic DNA.
Zhang KY, Leung HW, Yeung HW, Wong RN.
The RAPD (random amplified polymorphic DNA) technique was applied for the first time to distinguish Lycium barbarum from other closely related species of the same genus. In this study, eight samples were collected, including five species, two varieties and one cultivated variety. A total of fifty arbitrary primers were used in the RAPD analysis. Distinctive DNA fingerprints corresponding to different Lycium species were successfully obtained from ten primers. Similarity index (S.I.) analysis revealed that the values are higher between intraspecies than interspecies. These results confirmed that the RAPD technique can be employed for distinguishing closely related species of Lycium.
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PMID: 11458465 [PubMed - indexed for MEDLINE]
141: Carbohydr Res. 2001 Jun 22;333(1):79-85.
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Structural features of arabinogalactan-proteins from the fruit of Lycium chinense Mill.
Qin X, Yamauchi R, Aizawa K, Inakuma T, Kato K.
The United Graduate School of Agricultural Science, Gifu University, Science of Biological Resources, 1-1 Yanagido, Gifu 501-1193, Japan.
In addition to the other arabinogalactan-proteins (AGPs) (Cp-1-C and -D) already reported, two kinds of AGP (Cp-2-B and Hp-2-C) were obtained from the fruit of Lycium chinense Mill. The ratio of arabinose to galactose was approximately 1:1 in both samples, and the carbohydrate was linked O-glycosidically to serine in Cp-2-B, and to both serine and threonine residues of the protein in Hp-2-C. The weight-average molecular weight was 71,000 for Cp-2-B and 120,000 for Hp-2-C. Both samples also contained non-reducing terminal 3-O- and 4-O-substituted galacturonic acids. The ratio of 6-O-substituted galactose (linear part) and 3,6-di-O-substituted galactose (branching point) was almost unity in both samples, being obviously different from the case of Cp-1-C (predominant in the branching domain) and Cp-1-D (predominant in the linear domain). These results offer fresh insight into the grouping of the AGPs, based on the ratio of 6-O- and 3,6-di-O-substituted galactosyl residues.
PMID: 11423113 [PubMed - indexed for MEDLINE]
142: J Agric Food Chem. 2001 Jun;49(6):3106-12.
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Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants.
Miean KH, Mohamed S.
Faculty of Food Science and Biotechnology, University Putra Malaysia, 43400 Serdang Selangor, Malaysia.
Studies were conducted on the flavonoids (myricetin, quercetin, kaempferol, luteolin, and apigenin) contents of 62 edible tropical plants. The highest total flavonoids content was in onion leaves (1497.5 mg/kg quercetin, 391.0 mg/kg luteolin, and 832.0 mg/kg kaempferol), followed by Semambu leaves (2041.0 mg/kg), bird chili (1663.0 mg/kg), black tea (1491.0 mg/kg), papaya shoots (1264.0 mg/kg), and guava (1128.5 mg/kg). The major flavonoid in these plant extracts is quercetin, followed by myricetin and kaempferol. Luteolin could be detected only in broccoli (74.5 mg/kg dry weight), green chili (33.0 mg/kg), bird chili (1035.0 mg/kg), onion leaves (391.0 mg/kg), belimbi fruit (202.0 mg/kg), belimbi leaves (464.5 mg/kg), French bean (11.0 mg/kg), carrot (37.5 mg/kg), white radish (9.0 mg/kg), local celery (80.5 mg/kg), limau purut leaves (30.5 mg/kg), and dried asam gelugur (107.5 mg/kg). Apigenin was found only in Chinese cabbage (187.0 mg/kg), bell pepper (272.0 mg/kg), garlic (217.0 mg/kg), belimbi fruit (458.0 mg/kg), French peas (176.0 mg/kg), snake gourd (42.4 mg/kg), guava (579.0 mg/kg), wolfberry leaves (547.0 mg/kg), local celery (338.5 mg/kg), daun turi (39.5 mg/kg), and kadok (34.5 mg/kg). In vegetables, quercetin glycosides predominate, but glycosides of kaempferol, luteolin, and apigenin are also present. Fruits contain almost exclusively quercetin glycosides, whereas kaempferol and myricetin glycosides are found only in trace quantities.
PMID: 11410016 [PubMed - indexed for MEDLINE]
143: J Agric Food Chem. 2001 Jun;49(6):3101-5.
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Alpha-tocopherol content in 62 edible tropical plants.
Ching LS, Mohamed S.
Faculty of Food Science and Biotechnology, Universiti Putra Malaysia, 43400 Serdang Selangor, Malaysia.
Vitamin E was determined by the high-performance liquid chromatography (HPLC) method. All the plants tested showed differences in their alpha-tocopherol content and the differences were significant (p < 0.05). The highest alpha-tocopherol content was in Sauropus androgynus leaves (426.8 mg/kg edible portion), followed by Citrus hystrix leaves (398.3 mg/kg), Calamus scipronum (193.8 mg/kg), starfruit leaves Averrhoa belimbi (168.3 mg/kg), red pepper Capsicum annum (155.4 mg/kg), local celery Apium graveolens (136.4 mg/kg), sweet potato shoots Ipomoea batatas (130.1 mg/kg), Pandanus odorus (131.5 mg/kg), Oenanthe javanica (146.8 mg/kg), black tea Camelia chinensis (183.3 mg/kg),papaya Carica papaya shoots (111.3 mg/kg), wolfberry leaves Lycium chinense (94.4 mg/kg), bird chili Capsicum frutescens leaves (95.4 mg/kg), drumstick Moringa oleifera leaves (90.0 mg/kg), green chili Capsicum annum (87 mg/kg), Allium fistulosum leaves (74.6 mg/kg), and bell pepper Capsicum annum (71.0 mg/kg). alpha-Tocopherol was not detected in Brassica oleracea, Phaeomeria speciosa, Pachyrrhizus speciosa, Pleurotus sajor-caju, and Solanum melongena.
PMID: 11410015 [PubMed - indexed for MEDLINE]
144: Zhong Yao Cai. 2001 Feb;24(2):107-8.
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[Determination of four fractions of Lycium barbarum polysaccharides in different varieties]
[Article in Chinese]
Gan L, Zhang S.
Huazhong Agricultural University, Wuhan 430070.
The contents of four fractions of Lycium barbarum polysaccharides (LBP) in different varieties were analysed. This method can be used for quality evaluation of Fractus Lycii.
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PMID: 11402724 [PubMed - indexed for MEDLINE]
145: Mol Phylogenet Evol. 2001 May;19(2):246-58.
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Phylogeny and biogeography of the genus Lycium (Solanaceae): inferences from chloroplast DNA sequences.
Fukuda T, Yokoyama J, Ohashi H.
Biological Institute, Tohoku University, Sendai, 980-8578, Japan. fukuda@mail.cc.tohoku.ac.jp
Lycium comprises approximately 70 species and is disjunctly distributed in temperate to subtropical regions in South America, North America, southern Africa, Eurasia, and Australia. Among them, only Lycium sandwicense A. Gray sporadically occurs widely on oceanic islands in the Pacific Ocean. To investigate phylogenetic and biogeographic relationships of the genus with emphasis on L. sandwicense, the coding region of matK, the two intergenic spacers trnT (UGU)-trnL (UAA) and trnL (UAA)-trnF (GAA), and the trnL (UAA) intron of chloroplast DNA (cpDNA) were sequenced. A strict consensus tree resulting from the phylogenetic analysis indicates the following: (1) New World species comprise a potentially paraphyletic assemblage; (2) southern African, Australian, and Eurasian species together are monophyletic; (3) southern African species are a paraphyletic assemblage; and (4) L. sandwicense is in a clade with certain New World species. The estimated biogeographic events based on the cpDNA analysis indicate that (1) Lycium originated in the New World, (2) all southern African, Australian, and Eurasian species have a common ancestor from the New World, (3) Australian and Eurasian species originated once from a southern African progenitor, and (4) L. sandwicense differentiated from the New World species. Copyright 2001 Academic Press.
PMID: 11341807 [PubMed - indexed for MEDLINE]
146: Sheng Li Xue Bao. 1998 Jun;50(3):309-14.
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[The effect of lycium barbarum polysaccharide on vascular tension in two-kidney, one clip model of hypertension]
[Article in Chinese]
Jia YX, Dong JW, Wu XX, Ma TM, Shi AY.
Department of Pathophysiology, Beijing Medical University, Beijing 100083.
In the present study, the effects of lycium barbarum polysaccharide (LBP) on endothelial function in the two-kidney, one clip model of hypertension were observed. The results showed that the increase of blood pressure in hypertension rats (HR) could be prevented significantly by treatment with 10% LBP. In isolated aortic rings of LBP-treated rats, the contraction of phenylephrine (PE) was reduced as compared with HR rats. Removal of the endothelium abolished the difference of PE-induced vasoconstriction among groups. In vitro incubation of aortic rings from LBP-treated rats with methyl blue (MB) or N-nitro-L-arginine methyl ester (L-NAME) increased the magnitude of PE-induced contraction. Meanwhile the response to acetylcholine (ACh) was significantly increased in LBP-treated rats, but the response to nitroprusside had no significant difference among groups. Pretreatment with L-arginine partially restored ACh-induced relaxation in RH rats, but no effect in LBP-treated rats. These results suggested that the role of LBP in decreasing vasoconstriction to PE may be mediated by increase of the effects or/and production of endothelium-derived relaxation factor (EDRF). LBP increased formation of EDRF may be related to increase the substrate of EDRF.
Publication Types:
PMID: 11324572 [PubMed - indexed for MEDLINE]
147: Carbohydr Res. 2001 Mar 9;331(1):95-9.
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Structural characterization of the glycan part of glycoconjugate LbGp2 from Lycium barbarum L.
Peng X, Tian G.
State Key Laboratory of Bio-organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Academia Sinica, People's Republic of China.
A glycoconjugate with pronounced immunoactivity, designated as LbGp2, was isolated from the fruit of Lycium barbarum L. and purified to homogeneity by gel-filtration. Its carbohydrate content is up to 90.71% composed of Ara, Gal and amino acids. The molecular weight is 68.2 kDa as determined by size exclusive chromatography (SEC). The complete structure of the repeat unit of the glycan of LbGp2 was elucidated based on glycosidic linkage analysis, total acid hydrolysis, partial acid hydrolysis, 1H and 13C NMR spectroscopy. According to the experiments, the glycan possesses a backbone consisting of (1-->6)-beta-galactosyl residues, about fifty percent of which are substituted at C-3 by galactosyl or arabinosyl groups and the major nonreducing end being made of Ara (1 -->.
PMID: 11284511 [PubMed - indexed for MEDLINE]
148: Zhongguo Zhong Yao Za Zhi. 1997 Sep;22(9):532-3, 575.
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[Analysis of chromosome karyotype of Lycium chinense Mill.]
[Article in Chinese]
Jian Y, Ma Y, Peng Y, Zhu G.
Hunan College of Traditional Chinese Medicine, Changsha.
The chromosome karyotypes of wild Lycium chinese and its cultivated breeds for vegetable have been studied. The Chromosome 12 of both has a satellite. The former, with 24 chromosomes and 1B karyotype, is a diploid and its karyotype formula is 2n = 2x = 24 = 18m + 6sm. The chromosome number of the latter is 48. As a tetrploid, it has 2B karyotype and a karyotype formula 2n = 4x = 48 = 36m + 12sm.
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PMID: 11038941 [PubMed - indexed for MEDLINE]
149: Science. 2000 Sep 29;289(5488):2335-8.
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Comment in:
Polyploidy and the evolution of gender dimorphism in plants.
Miller JS, Venable DL.
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA. jsmiller@email.arizona.edu
Gender dimorphism and polyploidy are important evolutionary transitions that have evolved repeatedly in many plant families. We show that gender dimorphism in North American Lycium (Solanaceae) has evolved in polyploid, self-compatible taxa whose closest relatives are cosexual, self-incompatible diploids. This has occurred independently in South African Lycium. We present additional evidence for this pathway to gender dimorphism from 12 genera involving at least 20 independent evolutionary events. We propose that polyploidy is a trigger of unrecognized importance for the evolution of gender dimorphism, which operates by disrupting self-incompatibility and leading to inbreeding depression. Subsequently, male sterile mutants invade and increase because they are unable to inbreed.
Publication Types:
PMID: 11009416 [PubMed - indexed for MEDLINE]
150: Phytother Res. 2000 Sep;14(6):448-51.
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LCC, a cerebroside from Lycium chinense, protects primary cultured rat hepatocytes exposed to galactosamine.
Kim SY, Lee EJ, Kim HP, Lee HS, Kim YC.
Graduate School of East-West Medical Science, Kyunghee University, Seoul 130-701, Korea.
Primary cultures of rat hepatocytes exposed to galactosamine (GalN) were used as a screening system to assess whether a new cerebroside, LCC, isolated from the fruits of Lycium chinense, exhibits hepatoprotective activity. Cultured rat hepatocytes injured with GalN routinely release glutamic pyruvic transaminase (GPT) and sorbitol dehydrogenase (SDH) into the culture medium. Treatment of these GalN-injured primary cultures with LCC markedly blocked the release of both GPT and SDH in a dose-dependent manner over concentrations of LCC ranging from 1 microM to 10 microM. To investigate the mechanism of action for the hepatoprotective activity of LCC, the extent of [(3)H]-uridine incorporation into RNA was measured in GalN-injured cultures of rat hepatocytes. [(3)H]-Uridine incorporation was significantly decreased in injured hepatocytes. LCC, however significantly restored the incorporation of [(3)H]-uridine into RNA in a dose-dependent manner over concentrations ranging from 1 microM to 10 microM. LCC also blocked the suppression of RNA synthesis caused by actinomycin D in a dose-dependent manner. These data suggest that LCC may have prominent hepatoprotective activity and that its therapeutic value should be investigated further. Copyright 2000 John Wiley & Sons, Ltd.
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PMID: 10960900 [PubMed - indexed for MEDLINE]
151: Wei Sheng Yan Jiu. 1998 Mar;27(2):109-11, 115.
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[Scavenging effect of total flavonoids of lycium barbarum L on active oxygen radicals and inhibitory effects on heat output from L1210 cells]
[Article in Chinese]
Huang Y, Tan A, Shen Y, Lu J.
Dept. of Nutrition and Food Hygiene, Ningxia Medical College, Yinchuan, China.
The scavenging effects of total flavonoids of Lycium barbarum L. (TFL) were studied by using ESR-spin trapping technique and the inhibitory effects on heat output of both polymorphonuclear leukocyte(PMN) respiration burst and L1210 cells were measured by using microcalorimetric technique. TFL (0-217 mg/L) could scavenge O2-. in xanthine/xanthine oxidase (Xan/XO)system, with scavenging rate of 0-51%. TFL(7.5-200 mg/L)could scavenge OH. produced in Fenton reaction and the scavenging rate is between 20% to 72%. Those effects were concentration-dependent. Furthermore, TFL(0.56 g/L)could completely inhibit the heat output from PMA-stimulated PMN and TFL(1.0-5.0 g/L)could inhibit the heat output from L1210 cells.
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PMID: 10682619 [PubMed - indexed for MEDLINE]
152: J Chromatogr A. 1999 Oct 1;857(1-2):331-5.
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Determination of betaine in Lycium chinense fruits by liquid chromatography-electrospray ionization mass spectrometry.
Shin YG, Cho KH, Kim JM, Park MK, Park JH.
College of Pharmacy, Seoul National University, South Korea.
A rapid and sensitive high-performance liquid chromatography-electrospray mass spectrometric method has been developed for the determination of betaine in Lycium chinense fruits. Betaine was analyzed on a system consisting of a NH2 stationary phase and a mobile phase of water-acetonitrile (25:75) by isocratic elution for 40 min. Betaine was identified and quantitated by electrospray ionization mass spectrometry with selected ion monitoring of the protonated ion [Betaine+H]+ and clustered ions [nBetaines+H]+. The limit of detection for betaine by this method was ca. 0.2 ng/ml and the relative standard deviations of the assay (intra- and inter-day) were less than 8.1%.
PMID: 10536853 [PubMed - indexed for MEDLINE]
153: Biol Pharm Bull. 1999 Aug;22(8):873-5.
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A novel cerebroside from lycii fructus preserves the hepatic glutathione redox system in primary cultures of rat hepatocytes.
Kim SY, Lee EJ, Kim HP, Kim YC, Moon A, Kim YC.
College of Pharmacy, Seoul National University, Kwanak-Gu, Korea.
We previously reported the isolation of a novel cerebroside (1-O-(beta-D-glucopyranosyl)-(2S,3R,4E,8Z)-2-N-palmityloc tadecasphinga-4,8-diene; LCC) from the fruits of Lycium chinense MILL. (Solanaceae) which protected primary cultured rat hepatocytes from the toxicity induced by carbon tetrachloride (CCl4). The present study was conducted to determine the mechanism(s) by which LCC might exert its hepatoprotective activity. To determine the effect of LCC on the glutathione (GSH) redox system, we measured the activities of enzymes involved in the system as well as the levels of hepatic mitochondrial GSH and malondialdehyde (MDA). The hepatotoxicant, CCl4, routinely decreased levels of total and reduced GSH. The levels of these compounds were significantly maintained at the levels of the control cultures following treatment with LCC. The decreased activities of glutathione reductase and glutathione peroxidase in CCl4-injured rat hepatocytes were significantly increased by the treatment of LCC. Furthermore, the elevated levels of MDA seen in CCl4-injured rat hepatocytes were reduced after treatment with LCC in a concentration dependent manner over a range of 1-10 microM. From these results, we postulate that LCC may preserve the hepatic mitochondrial level of GSH by scavenging reactive oxygen species produced during CCl4-induced toxicity and thereby reduce lipid peroxidation and cellular damage.
Publication Types:
PMID: 10480330 [PubMed - indexed for MEDLINE]
154: Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Nov;13(4):322-5.
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[The injury of Xenopus laevis oocytes membrane and its acetylcholine receptor by free radical and the protection of lycium barbarum polysaccharide]
[Article in Chinese]
Zhang B, Zhang X, Li W.
Institute of Gerontology and Geriatrics, General Hospital of PLA, Beijing.
The injury of the Xenopus laevis oocytes membrane and its acetylcholine receptor by free radicals was observed by exposing Xenopus laevis oocytes to the xanthine oxidase hypoxanthine (XO-HPX) reaction system. The results showed that under the action of free radicals the passive electrical membrane parameters changed significantly, this effect was directly proportional to the concentration of XO-HPX and the reaction time. The membrane function was not affected by 2 hours reaction with XO-HPX, while significant decrease of various membrane functional indices was found after more than 4 hours reaction, the Ach polarization decreased, the rise time prolonged, the degree of depolarization decreased, the decay 1/2 time shortened. SOD may be used to eliminate the effect of free radicals on the above mentioned membrane parameters. Lycium barbarum polysaccharide (LBP) may be used to improve the passive electrical membrane parameters of the injured membrane, but it does not lead to the recovery of Ach depolarization. The results suggest that the injury of cell membrane and Ach receptor by XO-HPX reaction system may be caused by the production of O2- free radicals. LBP may antagonize the action of free radicals on the membrane while it is ineffective in muscarine receptor injury.
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PMID: 10322961 [PubMed - indexed for MEDLINE]
155: J Ethnopharmacol. 1999 Feb;64(2):101-8.
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Difference in the effects of radioprotection between aerial and root parts of Lycium chinense.
Hsu HY, Yang JJ, Ho YH, Lin CC.
Department of Cellular Biology, Tzu-Chi Medical College, Hualie, Taiwan.
Radiation protection from bone marrow death by consecutive injections of crude extracts from different parts of Lycium chinense (LC), root (LCR) and aerial part (LCA), before whole body X-irradiation was confirmed by tests with ICR strain mice. Both extracts were effective after intraperitoneal injection of a high dose, once a day, for seven consecutive days before irradiation. Based on the studies of endogenous hematopoietic spleen colony formation (CFUs), and the postirradiation behavior of hematograms and hematocrits, it was demonstrated that the LCR protects mice more effective when given in a dose of 500 mg/kg. Enhanced CFUs was found in the irradiation range of 4-8 Gy by various treatments. Recovery of leukocyte, erythrocyte and thrombocyte counts was significantly stimulated by the extract of LCR with 500 mg/kg administration. Stimulated recovery by the extract from the LCR was also observed in hematocrit. On the contrary, the extracts of both LCA and LCR did not markedly affect recovery of leukocyte, erythrocyte, thrombocyte counts and hematocrits by 250 mg/kg administration. It could be deduced that the uncertainly radioprotective action is induced by a possible process of enhanced regeneration of the hematopoietic stem cells due to either enhanced postirradiation repair or an increased proliferation of the hematopoietic stem cells under the suitable extract administration.
PMID: 10197745 [PubMed - indexed for MEDLINE]
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